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Ghost Seed Slay the Spire 2 — What the Ghost Seed Relic Does
Updated 2026-06-02
Ghost Seed Effect Explained
Ghost Seed is an uncommon relic in Slay the Spire 2. The tooltip says: "The first time you would die each combat, instead survive with 1 HP and become Intangible next turn."
This is a one-time save per combat, not per rest. It resets every fight.
Ghost Seed is great for aggressive builds that cut defense. If you rush enemies down and one bad turn kills you, Ghost Seed gives a second chance. The Intangible next turn means you take zero damage, letting you stabilize.
Weaknesses
It does nothing against multi-hit attacks that deal 1 HP. If an enemy hits you for 1 damage, it triggers but you still die to the second hit. It also does not protect against status damage like Burn or Poison tick after death.
FAQ
- Does Ghost Seed work against the Heart?
- Yes. The Heart's big multi-attack will trigger it once, then the Intangible next turn blocks the second big hit. A strong pick for Act 4.
- Does Ghost Seed stack with Lizard Tail?
- No. Lizard Tail and Ghost Seed both trigger on lethal damage. Ghost Seed has priority because it triggers first. Lizard Tail will not activate.
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