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Slay the Spire 2 Enemies — Full Bestiary Guide
Updated 2026-06-02
New Enemies Across All Acts
Slay the Spire 2 adds 24 new enemies on top of returning favorites from the original. Here is what you will fight in each act.
| Act | New Enemies | Returning Enemies | Boss |
|---|---|---|---|
| Act 1 | Cinder Imp, Rust Crab, Wandering Golem | Jaw Worm, Louse, Cultist | Hexaghost (reworked), Slime Boss |
| Act 2 | Clockwork Archer, Oracular Mask, Soul Leech | Byrd, Snecko, Chosen | Collector (new), Champ |
| Act 3 | Gravitic Horror, Mirror Knight, Void Weaver | Giant Head, Spheric Guardian, Nemesis | Time Eater (reworked), Awakened One |
| Act 4 | None unique | Spear and Shield (reworked) | Corrupt Heart |
Toughest New Enemy: Mirror Knight
Mirror Knight in Act 3 copies your last played card each turn. If you play a strong attack, it hits you with it. The counterplay is to lead with weak cards or use statuses. Poison and shiv builds struggle here.
FAQ
- Which act is the hardest in Slay the Spire 2?
- Act 3 is harder than in the original. Gravitic Horror and Mirror Knight both punish slow decks. Time Eater got new moves that scale with your card count.
- Did any original enemies get removed?
- Yes. Repulsor, Spire Growth, and Transient were cut. Snake Plant also did not return.
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