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Is Doom a Debuff in Slay the Spire 2? Status Effect Guide

Updated 2026-06-02

Is Doom a Debuff in Slay the Spire 2?

Yes, Doom is a debuff. It's one of the new status effects introduced in Slay the Spire 2. Think of it as a delayed execution. When an enemy has Doom, they take damage at the start of their turn for a set number of rounds.

PropertyDetail
TypeDebuff
Damage triggerStart of affected enemy's turn
DurationVaries by card (usually 2-4 turns)
StacksYes — multiple Doom applications extend duration
CleanseSome enemies can cleanse debuffs; Doom can be removed

Doom stacks additively for duration. If you apply Doom (2) and then Doom (2) again, the enemy takes damage twice over 4 turns. The Necrobinder class has the most access to Doom cards. It's a great tool for bosses with multi-turn attack patterns.

Watch out for enemies that cleanse debuffs. The Corrupted Scribe removes all debuffs every 3 turns, making Doom useless against it.

FAQ

Does Doom work on bosses?
Yes. Bosses take Doom damage just like normal enemies. It's especially effective against bosses with predictable attack patterns.
Can I apply Doom to myself?
No. Doom is enemy-only in the current build. Some Necrobinder cards deal self-damage, but Doom is never applied to the player.
Does Doom count as damage for kill effects?
Yes. If Doom kills an enemy, it triggers on-kill effects like the Necrobinder's Soul Harvest.

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